More Thought Needed on Causes versus Consequences in the Hallmarks of Aging – Fight Aging!

The hallmarks of aging are not a definitive list of causative mechanisms, but rather a description of aging phenotypes. However, an updated model of aging includes new pathways and highlights the need to shift focus towards identifying causative mechanisms for intervention. The proposed “three-wheeled gears” model separates early, intermediate, and late events of aging, emphasizing the interconnected nature of molecular, cellular, and phenotypic processes. It is crucial to target underlying mechanisms rather than just reverting aging symptoms. For more in-depth discussion, read the full article here.