Molybdenum Disulfide Structures Increase Mitochondrial Biogenesis
Researchers have conducted initial in vitro studies on a promising method to enhance mitochondrial function by boosting mitochondrial replication. While the transition from cell culture to therapeutic application is challenging, the uniqueness of this approach is intriguing. With the critical need for novel ways to improve mitochondrial function in aging tissues, the potential benefits of increased mitochondrial replication warrant further investigation. It remains uncertain whether this compensatory strategy will prove effective in restoring mitochondrial function in age-damaged environments.
The decline in mitochondrial function is implicated in various rare genetic disorders and common age-related metabolic and neurodegenerative conditions. Therefore, enhancing mitochondrial biogenesis has been proposed as a therapeutic avenue for these diseases. However, the current options for stimulating mitochondrial function are limited.
This study explores the use of molybdenum disulfide (MoS2) nanoflowers with predefined atomic vacancies to promote mitochondrial biogenesis. Treatment with these nanoflowers resulted in increased mitochondrial DNA replication and expression of key genes, enhancing mitochondrial respiratory capacity and ATP production in multiple cell types. By upregulating genes essential for mitochondrial biogenesis, MoS2 nanoflowers demonstrate a potential to boost mitochondrial function.
Link: https://doi.org/10.1038/s41467-024-52276-8
