Mechanisms for Amyloid Fibrils to Accelerate Calcification of Heart Valves
Amyloids are abnormal proteins that can disrupt normal cellular function by forming solid aggregates. In the context of heart health, amyloid fibrils have been implicated in accelerating the calcification of heart valves. This process, known as calcific aortic valve disease (CAVD), leads to the deposition of hydroxyapatite crystals on the heart valve leaflets, impairing cardiac function. Researchers have uncovered a molecular mechanism connecting amyloid deposition in the aortic valve to degenerative calcification, shedding light on potential treatment targets and risk factors for CAVD. Utilizing advanced cryogenic electron microscopy techniques, scientists have identified the structural features of amyloid fibrils that promote the formation of calcium phosphate crystals in the heart valve, further highlighting the role of amyloids in cardiovascular diseases. For more information, please visit the following link: Click here
