Researchers at the National University of Singapore have created a magneto-responsive hydrogel wound dressing that includes two different regenerative cell types. The hydrogel also contains magnetic particles that can be stimulated using an external magnetic field. This stimulation causes mechanical stresses within the gel to act on the cells, encouraging them to grow and enhancing their regenerative potential. The advanced dressing is designed to aid in the healing of diabetic wounds, which can be challenging to treat.
Wound healing can be impaired in diabetes, leading to chronic wounds that can result in amputation. Current wound dressings do not actively promote healing and frequent dressing changes can be costly and inconvenient. To address this, the researchers have developed an advanced diabetic wound dressing that actively encourages wound healing. The hydrogel dressing contains keratinocytes and fibroblasts, and when exposed to a magnetic field, the particles create mechanical stress on the cells to promote healing.
In tests, this magnetic/mechanical stimulation increased cell growth rates by 240% and doubled the amount of collagen produced. This approach not only accelerates wound healing but also promotes overall wound health and reduces the chances of recurrence.
A bandage pre-loaded with magnetic hydrogel is placed on the wound, and an external device is used to accelerate the wound healing process.
Study in journal Advanced Materials: Mechano‐Activated Cell Therapy for Accelerated Diabetic Wound Healing
Via: National University of Singapore
