Klotho is a pivotal longevity-associated gene that impacts life span in both directions. Research has primarily focused on its protective role in the kidneys, with recent studies indicating its potential in slowing aging in the brain. The study discussed here examines human data to support the development of therapies based on an optimized α-klotho version, as lower levels of circulating α-klotho are associated with increased risk of age-related diseases and mortality. This research suggests that therapies to increase circulating α-klotho levels may emerge before a complete understanding of its beneficial effects is achieved.
The prognostic significance of serum α-klotho in age-related diseases is a focus of this study, which analyzed data from the National Health and Nutrition Examination Survey. The findings indicate that individuals with low serum α-klotho levels are at significantly higher risk of all-cause and cardiovascular mortality. This suggests that low serum α-klotho concentration could serve as a marker of mortality risk in the general population and among those with age-related diseases.
The article “Low Serum α-Klotho Correlates with Raised Risk of Age-Related Mortality – Fight Aging!” delves into the findings of a study examining serum α-klotho levels and their association with mortality risk in age-related diseases. The research provides valuable insights into the potential prognostic significance of α-klotho in predicting all-cause and cardiovascular mortality in various populations.
