Investigating the Mechanisms by which Intermittent Fasting is Protective of the Liver – Fight Aging!

Investigating the mechanisms by which intermittent fasting protects the liver is a popular area of scientific study. Calorie restriction has been shown to have beneficial effects on metabolism and aging in animal studies. While calorie restriction mimetic drugs have been developed, they have not been proven to be as effective as actual calorie restriction. Despite this, even mild calorie restriction in humans has shown significant health benefits. Intermittent fasting has been found to protect against liver inflammation and liver cancer. Research has identified key molecular players, such as PPARα and PCK1, that are responsible for the protective effects of fasting. A 5:2 intermittent fasting regimen has been found to prevent NASH development and improve established MASH and fibrosis without affecting overall calorie intake. The timing, duration, and frequency of fasting cycles all play crucial roles in the benefits of fasting. Overall, intermittent fasting shows promise as an intervention against liver diseases.