The choroid plexus plays a crucial role in producing and filtering cerebrospinal fluid, as well as in regulating neurotrophic factors essential for brain health. As we age, there is a decline in cerebrospinal fluid production, impacting brain function. Researchers are studying age-related changes in the choroid plexus to better understand how aging affects brain health. This investigation sheds light on the transcriptional changes in the choroid plexus during aging, highlighting the potential impact on cerebrospinal fluid production and neurotrophic factor regulation. Learn more about this study by following the link: https://doi.org/10.1186/s12987-024-00574-0.