In Search of New Ways to Target Senescent Cells for Destruction
A variety of approaches are being explored to selectively eliminate senescent cells in aged tissues, with the goal of developing senolytic drugs. The research community is actively investigating the biochemistry of senescent cells to discover additional methods for their destruction. Given the complex nature of senescent cell biology and challenges in drug delivery, it is likely that a diverse range of therapies tailored to specific tissue types and age-related conditions will form a comprehensive senolytic toolkit.
The accumulation of senescent cells is implicated in age-related decline and the development of various age-related diseases. Immunotherapy targeting senescence-associated cell surface molecules shows promise in removing these cells selectively. Our study aims to fill a gap in knowledge by analyzing the cell surface proteome of senescent cells across different induction methods and cell types. Using mass spectrometry, we identified changes in surfaceome expression profiles during senescence and discovered unique cell surface proteins that could serve as targets for senotherapeutic interventions. These findings offer insights into detecting and targeting senescent cells in aging and age-related conditions.
Link: https://doi.org/10.1111/acel.14312
