Recent studies have shown that an increase in hydrogen sulfide in tissues can have a positive impact on aging by upregulating autophagy in muscle tissue. This mechanism is one of the many interventions that can slow down the aging process. While calorie restriction has been known to extend the lifespan of short-lived laboratory species through improved autophagy, it may not have the same effect on long-lived mammals or humans. However, hydrogen sulfide has shown promising results in alleviating muscle atrophy and aging-related issues in humans.
As individuals age, there is a natural decline in muscle mass and function, which can lead to various health issues. Hydrogen sulfide, a gasotransmitter produced in mammals, has been found to play a crucial role in reducing oxidative damage and enhancing muscle health. Studies suggest that H2S can alleviate muscle atrophy caused by diabetes and obesity through various mechanisms, including antioxidant stress, regulation of energy metabolism, and upregulation of autophagy.
This study aimed to investigate the role of hydrogen sulfide in enhancing the expression and S-sulfhydration of USP5, leading to the upregulation of autophagy and ultimately contributing to the alleviation of skeletal muscle aging. The results indicate a promising potential for hydrogen sulfide in combating age-related muscle issues.
For more information, you can refer to the full research article here: https://doi.org/10.1002/jcsm.13560.
