HDAC3 Inhibition Improves Memory Reconsolidation in Old Mice
Long-term memories require flexibility and updating to remain relevant. Recent research shows that inhibiting HDAC3 can help address memory maintenance issues in older mice. Interestingly, this approach may disrupt initial memory formation in younger mice, shedding light on how neurological aging mechanisms work. Understanding the nuances of mammalian memory function is crucial for addressing brain aging effectively.
Long-term memories are dynamic and must be updated to incorporate new information. Memory reconsolidation plays a key role in this process by destabilizing and updating existing memories. Age-related impairments in memory updating are linked to the repressive effects of HDAC3, a regulator of memory formation. By blocking HDAC3 with the inhibitor RGFP966, researchers were able to improve memory updating in older mice. Surprisingly, HDAC3 inhibition in young mice impacted the expression of original and updated information, highlighting the complex nature of memory regulation.
Further experiments showed that HDAC3 inhibition enhanced memory updating in young mice without affecting original memory, balancing the expression of both types of information. This suggests that HDAC3 may play a role in age-related memory impairments and regulate the strength of memory updates in younger individuals. By understanding how HDAC3 influences memory processes, researchers can pave the way for more effective interventions in brain aging.
Link: https://doi.org/10.3389/fnmol.2024.1429880
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