Researchers at this institution have conducted a study using mice with interconnected circulatory systems to investigate factors involved in skin aging. Their findings suggest that decreased levels of HAPLN1 may play a significant role in skin aging, as the introduction of recombinant HAPLN1 has shown promise in improving skin aging markers. While the exact mechanisms of action are still being studied, it is crucial to understand why HAPLN1 levels decrease with age. Instead of focusing on individual molecules, it is essential to identify and address the root causes of aging.
Additionally, heterochronic parabiosis has been utilized to study the systemic effects of aging on skin regeneration. Through precise procedures approved by animal care committees, researchers have demonstrated that HAPLN1, a protein that decreases with age, plays a crucial role in maintaining collagen and hyaluronic acid levels in the skin. HAPLN1 functions by promoting the formation of water-rich aggregates in the pericellular matrix, contributing to anti-oxidation, anti-senescence, and possibly anti-inflammation processes. Substituting HAPLN1 could be a promising strategy for rejuvenating aging skin.
For more information, please refer to the following link: Link: https://doi.org/10.1016/j.matbio.2024.08.009
