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Exploring the Link Between Bone Marrow Aging and Neuroinflammation: Researchers in an open access paper discuss how changes in bone marrow aging play a role in chronic inflammation in aging brains. This inflammation is critical in the development of neurodegenerative diseases like Alzheimer’s, impacting brain function. With age, there is a shift towards the production of innate immune cells over adaptive immune cells in bone marrow, but this is just one of many alterations that occur with aging.
The immune system of the brain, while distinct, is influenced by the body’s immune system, with changes in the bone marrow affecting brain immunity. Aging is a complex process with physiological changes, including immunosenescence and neuroinflammation, impacting neurological disorders.
Our review aims to explain how bone marrow aging influences immunosenescence, inflammation, and neuroinflammation, particularly in age-related neurological diseases, providing insight into potential therapeutic interventions for elderly individuals.
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Understanding the Impact of the Aged Gut Microbiome on Inflammation: Aging leads to changes in the gut microbiome, with harmful microbes increasing and beneficial ones decreasing, triggering chronic inflammation. Researchers have found that aging affects the immunogenic capacity of the gut microbiota, driving inflammation, which can be passed on to younger individuals through a fecal transplant.
Old age alters how the gut microbiota influences the innate immune system, exacerbating chronic inflammatory diseases affecting older populations disproportionally. These microbiota signatures are crucial in mediating host inflammatory responses.
Discover more about how the gut microbiome influences inflammation on our website.
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Harnessing the Power of Exercise to Boost Neurogenesis: Exercise is known to enhance cognitive function and neurogenesis, the process of creating new neurons essential for brain health. Research demonstrates that exercise can reverse age-related changes in microglia, the brain’s immune cells, and improve synaptic connections in the brain.
Microglia play a crucial role in neuroplasticity, and their inflammatory response can impair cognitive function. Exercise has been shown to reduce inflammation and rejuvenate microglia, contributing to improved brain health in aging individuals.
Learn more about the rejuvenating effects of exercise on our website.
