Researchers are using Mendelian randomization to investigate causation in human epidemiological data by looking at gene variants associated with outcomes. This method is applied to study the link between epigenetic age and neurodegenerative diseases like Alzheimer’s.
The relationship between neurodegenerative diseases, epigenetic aging, and human longevity is not well understood. By analyzing large-scale genetic data, causal associations and shared genetic factors are being explored. Studies show a potential causal link between Alzheimer’s disease and epigenetic age acceleration. Shared genetic loci were identified, shedding light on possible biological mechanisms.
Interestingly, only Alzheimer’s disease was found to have causal effects on epigenetic aging and longevity, indicating a unique relationship compared to other neurodegenerative diseases. The genetic overlap suggests complex shared genetic factors and molecular pathways.
