Exercise is known to reduce the risk of cardiovascular disease, with studies showing a correlation between physical activity and improved cardiovascular outcomes. Researchers have found that stress also plays a significant role in cardiovascular health, especially in patients with conditions like major depressive disorder. To understand the mechanisms behind these benefits, a study analyzed data from over 50,000 participants. The results showed that meeting physical activity recommendations led to a 23% lower risk of cardiovascular disease. Additionally, higher levels of physical activity were associated with lower stress-related brain activity, particularly in the prefrontal cortex. This reduction in stress signaling partially explained the cardiovascular benefits of exercise, especially in individuals with depression. The study suggests that the effects of exercise on the brain’s stress response may play a crucial role in reducing cardiovascular risk, particularly in individuals with high stress-related brain activity. The findings highlight the importance of physical activity in maintaining cardiovascular health, especially for those dealing with stress and depression. [Link to the article: https://www.eurekalert.org/news-releases/1040861]