Senescent cells in old tissues are believed to be harmful, with treatments aimed at removing these cells expected to reverse aspects of aging and age-related diseases. These cells secrete inflammatory molecules that disrupt tissue structure and function when present long-term. As individuals age, the body struggles to clear these cells efficiently, leading to a buildup throughout the body. One key area where senescent cells impact is the vasculature, particularly in endothelial cells found in blood vessel walls. Senescent endothelial cells contribute to a decline in capillary density, reducing blood flow and nutrient delivery to tissues. Therapies targeting senescent cells show promise in reversing age-related vascular dysfunctions.
The presence of senescent cells, specifically in endothelial cells, plays a crucial role in age-related vascular dysfunction. The loss of capillary density due to senescent endothelial cells impacts tissue function, particularly in energy-demanding tissues like the brain and muscles. Senolytic therapies that target senescent cells offer potential in reversing this aspect of aging. Researchers emphasize the importance of clearing senescent cells to improve cardiovascular health and combat age-related diseases.
Cellular senescence, characterized by the permanent growth arrest of somatic cells, contributes to age-related tissue degeneration. Senescent cells secrete a variety of factors that reprogram the microenvironment, leading to tissue damage and promoting aging-related diseases. Interventions targeting senescent cell accumulation have shown promising results in delaying aging and extending lifespan. Endothelial senescence, particularly in the microvasculature, leads to a decline in capillary density, reduced angiogenic potential, and impaired blood flow, highlighting the importance of targeting senescent cells to improve health-span and life-span.
