There is a significant difference in life expectancy between sexes in many species, including humans. While many hypotheses exist to explain this difference, recent research suggests that germline cells play a crucial role in determining life span differences between males and females. By removing germline cells in killifish, researchers found that females’ life spans shortened while males’ life spans extended. This discovery sheds light on the role of reproductive strategies in influencing life span differences between sexes. Further research is needed to investigate the specific mechanisms involved in this process.
The study, titled “Sex-dependent regulation of vertebrate somatic growth and aging by germ cells,” provides insight into how germ cells impact somatic growth and aging in vertebrates. The research conducted on Nothobranchius furzeri showed that germ cell removal led to differences in estrogen and insulin-like growth factor 1 (IGF-1) signaling in females, while males showed improved health with increased vitamin D signaling. These findings highlight the complex interplay between germ cells and the endocrine system in regulating somatic growth and aging, with potential implications for understanding the sexual differences in reproductive strategies.
