Recent research has suggested a potential link between gum disease (periodontitis) and cardiovascular disease and neurodegenerative conditions. Pathogens and harmful metabolites leaking into the bloodstream from the gums can lead to chronic inflammation, which may contribute to the development of these diseases. While there is some debate over the extent of the risk, there is evidence that aging plays a role in the development of periodontitis and cardiovascular disease.
A study utilizing Mendelian randomization analysis explored the relationship between aging, periodontitis, and cardiovascular disease. The results supported the idea that aging contributes to both periodontitis and cardiovascular disease, while periodontitis itself can also contribute to cardiovascular disease. Further analysis revealed a potential causal effect of periodontitis on small-vessel stroke and the impact of aging on specific cardiovascular diseases. This study sheds light on the complex interplay between aging, periodontitis, and cardiovascular disease.
Examining data from the NHANES database, researchers found that an increase in periodontitis severity was associated with a higher risk of cardiovascular disease, including small-vessel stroke. The systemic inflammation caused by periodontitis, as indicated by elevated inflammatory markers in patients with gum disease, may play a key role in the pathophysiology of cardiovascular disease. Additionally, the study uncovered evidence suggesting a link between biological aging, periodontitis, and cardiovascular disease, highlighting the intricate relationship between these factors.
