Correlations with Mortality in Levels of Proteins Secreted by Senescent Cells – Fight Aging!

Researchers are exploring the link between late life mortality and specific proteins produced by senescent cells as part of the senescence-associated secretory phenotype (SASP). It’s interesting to note that the levels of these molecules don’t always align with senescent cell burden, possibly due to their signaling roles in various cell types. The study delves into 28 SASP proteins and their correlation with mortality risk in older adults with promising results. Biomarkers like GDF15, RAGE, VEGFA, PARC, and MMP2 were identified as strong predictors of death, highlighting the potential of cellular senescence biomarkers in predicting health outcomes in aging individuals. These findings support the use of SASP proteins as informative tools for assessing mortality risk in the elderly population. [Link: https://doi.org/10.1111/acel.14006]