Connecting Changes in the Gut Microbiome to Hematopoietic Stem Cell Aging
Researchers now recognize a mutual relationship between aging of the gut microbiome and aging of the immune system. The immune system regulates the gut microbiome to control harmful microbes, but an increase in inflammatory microbes can lead to immune dysfunction. Interactions between these systems are crucial in aging processes. Enhancing late-life immune function can improve the gut microbiome, and vice versa.
Recent studies have highlighted the gut-bone marrow axis, connecting the gut microbiome to the hematopoietic system. Both systems undergo changes with age, emphasizing the need to understand their relationship and mutual effects. The gut microbiota plays a role in hematologic disorders and HSC maintenance, with various mediators like SCFAs and bacterial molecules influencing the gut-bone marrow axis and aging.
Link: Research Article
