Cellular senescence is a process that occurs throughout life, contributing to tissue regeneration and cancer prevention. However, in later life, the accumulation of senescent cells leads to chronic inflammation and contributes to the aging process. This process is also implicated in age-related cognitive decline and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. Understanding the role of senescence in cognitive decline is crucial, especially in the development of potential treatments for these conditions.
The mechanisms underlying brain aging have garnered significant attention due to the significant number of patients suffering from dementia and Alzheimer’s disease. Age-related cognitive decline can be attributed to processes governing biological aging, including cellular senescence. Studies have shown a causal relationship between the accumulation of senescent cells and age-related tissue dysfunction, particularly in the brain. Understanding the role of senescence in cognitive decline is essential, especially considering the rapidly evolving field of senotherapeutics. Targeting senescent cells could mitigate early brain aging and reduce a significant burden on patients, healthcare systems, and society.
