Can Polyphenol Senotherapeutics be Improved with the Use of Nanocarriers? – Fight Aging!
The development of supplements and interventions based on plant extracts may be driven by cost-effective regulatory approval processes, but there are some plant extracts that show promise in targeting senescent cells. Piperlongumine and fisetin, for example, have shown potential in selectively killing these harmful cells. However, their bioavailability is a challenge, leading researchers to explore the use of nanocarriers such as polymer nanoparticles and lipid vesicles to enhance their efficacy. Continued research in this area is encouraged to improve the effectiveness of senolytic therapies and reduce the negative effects of cellular senescence.
