Brain Cells Exhibit Maladaptive Changes in Response to an Aged Signaling Environment
How much of the declining function characteristic of aging is a matter of accumulated damage versus maladaptive responses to that damage? This article explores the impact of an aged signaling environment on brain cells, discussing the role of immune receptors and their contribution to neuroinflammation and neurodegeneration. The chronic inflammation in the aging brain sets up a positive feedback loop, leading to permanent synaptic and neuronal loss.
Link: https://doi.org/10.1042/BSR20222267
