Blocking cGAS-STING Inflammatory Signaling Protects the Retina for Glaucoma – Fight Aging!

Researchers have discovered that retinal degeneration may be partly driven by maladaptive innate immune signaling through the cGAS-STING pathway. This pathway is a focus of research as a potential target to interfere with chronic inflammation seen in aging and degenerative diseases. However, distinguishing between harmful and necessary inflammatory signaling remains a challenge. In the case of glaucoma, the loss of retinal ganglion cells plays a crucial role in vision loss. Various mechanisms, including oxidative stress and DNA damage, contribute to this cellular loss. Studies indicate that targeting the cGAS-STING pathway may offer protective effects against RGC loss, making it a promising therapeutic strategy. You can read more about this study at the provided link: Link: https://doi.org/10.18632/aging.205900.