Margo Wickersham, a 57-year-old real estate professional, was diagnosed with stage 1 bladder cancer with no known risk factors. During treatment, she discovered she had a rare type of bladder cancer called plasmacytoid cancer, leading to the removal of her bladder. Bladder cancer survivors are at high risk of developing second primary cancers, with lung cancer being the most common. Factors such as smoking, exposure to carcinogens, and genetic mutations contribute to the increased risk. Regular screenings and healthy lifestyle choices can help reduce the risk of second cancers in survivors.