Researchers in the field of aging research have been discussing the impact of the hallmarks of aging paper and its subsequent expansions. This review aims to evaluate the influence of the Hallmarks and determine if the purpose for which they were created has been achieved. The literature review shows that the Hallmarks have significantly influenced various areas of aging research and related fields, serving as a model for organizing knowledge and inspiring further studies. The updated version of the Hallmarks, with its additional hallmarks, has also had a notable impact and is already influencing studies. However, it is important to acknowledge the limitations of the Hallmarks and consider the latest advances in determining their validity and the potential inclusion of new hallmarks. While the current Hallmarks of Aging provide a valuable framework for research, it is evident that updated versions will be necessary as knowledge in the field continues to evolve.
Link: https://doi.org/10.3389/fragi.2024.1334261
