Aspects of Skin Aging Encourage Metastasis in Melanoma
Research suggests that the aging of skin tissue plays a significant role in the metastasis of melanoma. Specific changes in aged skin tissue, such as increased stiffness due to decreased levels of the protein HAPLN1, can indirectly contribute to the spread of cancer cells to other organs. This alteration in cell signaling leads to an increase in ICAM1 levels, promoting angiogenesis and facilitating tumor growth and metastasis. Targeting ICAM1 with drugs has shown promising results in reducing tumor size and metastasis in older mice with melanoma. This discovery may pave the way for novel approaches to treating age-related cancers. For more information, you can visit here.
