An Epigenetic Clock Using Retrotransposon DNA Methylation
An aging clock can be developed using machine learning from large sets of biological data that change with age. While various aging clocks are being created, efforts are being made to standardize a few accepted clocks to focus resources on advancing rejuvenation and age-slowing therapies. Establishing consensus on the best clock is crucial for research progress.
Reactivation of retroelements in the human genome is associated with aging. Our research shows that retroelement DNA methylation can be used to create accurate retroelement-based epigenetic clocks that determine chronological age in humans and other mammals. Our clock, constructed from unique CpGs, offers valuable insights into aging biomarkers and the role of retroelements in geroscience.
Link: https://doi.org/10.1111/acel.14288
