The role of proteasomes in cellular function is crucial, as they are responsible for the regulation of protein turnover and quality control. In Alzheimer’s disease, the impairment of proteasomal function has been observed, leading to the accumulation of unwanted proteins and contributing to neurodegenerative symptoms.
A recent study delved into the impact of amyloid-β, a hallmark of Alzheimer’s disease, on synaptic proteasomal function. The findings revealed that amyloid-β oligomers inhibit synaptic proteasome activity and lead to a reduction in synaptic proteasome content. Furthermore, the study demonstrated that this inhibition can result in AD-like pathological features and memory impairment in mice.
These results highlight the importance of addressing proteasomal function in the context of Alzheimer’s disease, both through the clearance of amyloid-β and the development of strategies to enhance proteasomal activity. By understanding and addressing the role of proteasomes in synaptic function, researchers aim to uncover new avenues for therapeutic interventions in Alzheimer’s disease.
