Alternative Polyadenylation in Nematode Aging and Longevity – Fight Aging!

Polyadenylation is a crucial process in mRNA creation, involving the addition of a poly(A) tail to protect the molecule during translation. Recent research on nematode worms reveals age-related changes in polyadenylation, affecting protein production and longevity. Can interventions reverse this dysfunction? Single-cell sequencing shows promise in understanding cell-specific effects of aging and pro-longevity strategies. Alternative polyadenylation plays a vital role in mRNA regulation, signaling potential interventions to improve protein output and longevity.