The immune system is a complex network that goes beyond defending against pathogens. Immune cells play a role in tissue maintenance and signaling, affecting the behavior of other cell populations. This connection between the immune system and tissue structure is crucial in understanding aging and rejuvenation efforts.
Aging leads to changes in the immune system, resulting in immune aging characterized by chronic inflammation and reduced defense ability. This leads to increased morbidity and mortality in the elderly. T cells with aging phenotypes accumulate with age, exacerbating immune aging and impacting immune function.
Studies have shown that aging T cells can contribute to pathological changes in tissue structure through mechanisms such as promoting inflammation, failing to clear senescent cells, and damaging tissues. These effects can lead to various diseases and impact the health of the elderly.
Link: https://doi.org/10.1186/s12979-024-00433-4
