Advocating for Extracellular Vesicle Therapies to Treat Neurodegenerative Conditions – Fight Aging!
Extracellular vesicles, small membrane-wrapped packages of molecules, hold promise as a replacement for stem cell therapy. Stem cell-derived extracellular vesicles have shown immunomodulatory effects, particularly in reducing inflammation, which is a key factor in neurodegenerative conditions like Alzheimer’s Disease, Parkinson’s Disease, and stroke. These vesicles have the ability to cross the blood-brain barrier and provide therapeutic benefits within the brain, while also offering advantages such as longevity, immune regulation, and potential for engineering to enhance targeting and therapeutic outcomes. Despite some challenges in efficiency and consistency, strategies for engineering and applications of these extracellular vesicles are being explored in various neurological disorder models, paving the way for potential clinical translation and solutions to address existing limitations.
