A Survey of MicroRNAs Shown to be Relevant to Muscle Aging – Fight Aging!

RNA molecules are essential players in cell functions, with microRNAs being a key type that directly impact gene expression. In the context of aging muscle tissue, certain microRNAs have been identified as crucial in the decline of tissue maintenance and regeneration. Therapies targeting specific microRNAs are emerging, offering hope for improved muscle function in later life. Non-coding RNAs, including microRNAs, are pivotal in regulating various cellular processes, with research revealing their significance in muscle aging. For instance, miRNAs like miR-29, miR-143, and miR-431 may enhance age-related muscle regeneration. Understanding the roles of microRNAs such as miR-501-3p and miR-7a-1 sheds light on their involvement in muscle regeneration and aging. Additionally, senescence-associated miRNAs like miR-24 play crucial roles in cellular senescence and muscle viability. Targeting specific microRNAs associated with sarcopenia, such as those within the Dlk1-Dio3 cluster, shows promise in preserving muscle function. Strategies involving miRNAs, such as miR-376c, miR-668, and miR-181a, offer potential for improving muscle health and function in older individuals. Understanding the regulatory mechanisms controlled by microRNAs could pave the way for innovative therapies targeting muscle aging.