In a recent study, researchers shed light on age-related circadian dysfunction, revealing a mismatch in regulation between the central circadian clock and peripheral clocks. As complex systems governing circadian rhythms begin to falter with age, the presence of multiple mismatched circadian regulators exacerbates tissue dysfunction. The intricate communication between the brain and peripheral clocks is vital for preserving muscle function and combating premature aging. Through the implementation of time-restricted feeding, the restoration of circadian rhythms shows promising results in mitigating muscle loss and enhancing metabolic and motor functions in aged subjects. This research underscores the critical role of synchronizing central and peripheral circadian clocks in maintaining tissue health and function. Understanding the signaling factors involved in this interaction could lead to innovative therapeutic interventions in the future.
Link: https://www.irbbarcelona.org/en/news/scientific/synchronisation-between-central-circadian-clock-and-circadian-clocks-tissues
