A Bidirectional Relationship Between AMPK and α-Klotho Expression – Fight Aging!

Klotho, a protein linked to longevity, shows a bidirectional relationship with health outcomes. In humans, its expression correlates with late-life health. The circulating form, α-klotho, interacts with cell receptors to benefit kidney and cognitive function. Research on α-klotho is ongoing, revealing its complex role in tissue function regulation. A recent study explores the reciprocal regulation between AMPK and α-klotho, shedding light on potential therapeutic interventions. This relationship holds promise for understanding and potentially manipulating cellular processes related to growth and maintenance.