Chronic inflammation associated with aging poses a threat to health, stemming from senescent cell accumulation and maladaptive responses to molecular damage. While short-term inflammation serves a protective role, persistent inflammation disrupts tissue structure and function, negatively impacting overall health. By exploring innovative omics-based methods to assess inflammation, researchers uncovered multi-omics risk scores that outperformed traditional biomarkers in predicting all-cause mortality. These findings offer valuable insights into the complex interplay between inflammation, aging, and lifespan, providing a foundation for improved risk assessment and potential interventions.
Inflammation plays a crucial role in chronic diseases, aging progression, and overall lifespan. Utilizing omics signatures, researchers developed multi-omics-multi-marker risk scores to evaluate inflammation status based on circulating inflammatory markers. Compared to single-omics risk scores, these multi-omics assessments demonstrated superior predictive capabilities for all-cause mortality in the Canadian Longitudinal Study on Aging and other relevant studies. By integrating genetics, metabolomics, and epigenetics, these novel approaches offer a comprehensive understanding of inflammation burden beyond conventional blood biomarkers, ultimately enhancing our ability to predict aging outcomes and lifespan.
