The gut microbiome composition plays a crucial role in long-term health and aging, potentially as impactful as lifestyle choices like exercise. Changes in microbial populations with age can lead to increased inflammation and decreased production of beneficial metabolites. While therapies like fecal microbiota transplantation show promise in altering the gut microbiome, more research is needed to ensure safety and efficacy. Understanding the association between gut microbiome and age-related conditions like sarcopenia could offer new therapeutic approaches to combat age-related dysfunction and decline. A recent review explores the link between gut microbiome and muscle mass, strength, and performance in older adults, highlighting the potential for interventions like probiotics and prebiotics to improve muscle health.