The aging process is accompanied by various degenerative conditions that affect the muscles and bones, largely due to the accumulation of senescent cells throughout the body. Senescent cells, triggered by factors such as reaching replication limits and cellular damage, release harmful signals that disrupt tissue structure and function. Osteoporosis, sarcopenia, and osteoarthritis are common musculoskeletal disorders prevalent in the elderly, leading to bone and muscle loss, cartilage degradation, and increased fracture risk. Understanding the role of cellular senescence in these diseases is crucial for developing effective management strategies. Studies suggest that senescent cells contribute to the decline in regenerative function in muscle and bone stem cells, leading to tissue metabolism alterations. Eliminating senescent cells in mouse models has shown improvements in bone density, muscle function, and cartilage health, highlighting the potential of senolytics in treating these conditions.
Senescent Cells in the Aging of Muscles and Bone – Fight Aging!
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