A Tissue Model of Wrinkle Formation
A tissue model can revolutionize research by offering a cost-effective and efficient alternative to animal models, particularly in studying age-related conditions. The development of a tissue model for wrinkle formation shows promise, as it aims to replicate the mechanisms of aging skin. The model’s success will be closely scrutinized in the coming years due to significant interest in understanding skin aging.
Despite the importance of biological wrinkle structures, research has mainly relied on animal models, limiting our understanding of wrinkle formation in living tissue. However, a recent breakthrough in creating a tissue model using human epithelial cells and ECM has provided new insights. By applying compressive forces, researchers were able to replicate wrinkle structures seen in various tissues. Factors like the ECM’s structure, dehydration, and compressive forces play a crucial role in wrinkle formation, mirroring the process observed in aging skin.
For more information, you can visit the link: https://www.postech.ac.kr/eng/the-mystery-of-human-wrinkles-what-do-the-cells-say/
