The Excess of Pro-Inflammatory Macrophages in Aged Sarcopenic Muscle – Fight Aging!

The aging process is often accompanied by chronic inflammation, particularly in the skeletal muscle. This inflammation is driven, in part, by an excess of pro-inflammatory macrophages in aged sarcopenic muscle. These macrophages, which should assist in tissue repair and regeneration, are instead polarized towards a harmful pro-inflammatory state. This shift negatively impacts the muscle’s ability to heal and maintain function over time. Understanding and addressing these immune changes in aging muscle may hold the key to combating age-related muscle loss and dysfunction.