It is important to explore the impact of beneficial lifestyle choices on biomarkers typically associated with pharmaceutical interventions. Calorie restriction and exercise have shown promise in slowing down degenerative aging, surpassing other available options. While this situation is disappointing, further research may lead to the development of more effective therapies.
A recent study highlighted how a short healthy lifestyle program improved functional outcomes for older individuals in Long-Term Care facilities. Although lifestyle interventions can have anti-aging effects by influencing oxidative stress and mitochondrial function, the exact mechanisms are still unclear. This study aimed to investigate the mechanisms behind the benefits of a short lifestyle program in older individuals by examining markers of oxidative stress and immunosenescence pre and post-program. The study looked at the effects of plasma from individuals who underwent the program on endothelial cells.
The study divided 54 older individuals into two groups: one undergoing the lifestyle program and a control group. The program included caloric restriction, physical activity, and psychological intervention over 3 months. Blood samples were taken before and after the program to assess markers of oxidative stress and immunosenescence. Results showed improvements in oxidative stress markers and maintenance of Tβ4 levels in the group that underwent the program. Additionally, endothelial cells treated with plasma from the program group showed positive changes in cell viability and mitochondrial function.
