Evidence for Metformin to Modestly Slow Aging in Non-Human Primates – Fight Aging!

Research on the potential anti-aging effects of metformin in non-human primates has shown promising results. While the evidence is not as robust as other anti-aging compounds like rapamycin, studies have demonstrated that metformin can slow biological aging in tissues such as the lung, kidney, liver, skin, and the brain’s frontal lobe. This was observed in a study where elderly male cynomolgus macaques were treated with metformin for 40 months, resulting in reduced chronic inflammation and activation of a protective protein called NRF2 in the brain. While the drug did not extend lifespan, it did enhance healthspan, indicating potential benefits in promoting healthy aging. For more information, visit the article here: https://doi.org/10.1038/d41586-024-02938-w.