The susceptibility of the elderly to infectious diseases is influenced by the age-related decline in the immune system. Other factors, such as blood-brain barrier leakage, can also play a role in making older individuals more vulnerable. Neurocryptococcosis, a fungal infection of the central nervous system, is more common in the elderly. Researchers discuss the reasons behind this phenomenon, including the reactivation of latent infections and age-related immune system changes.
Neurocryptococcosis, caused by Cryptococcus neoformans and C. gattii, is increasingly seen in older individuals due to various factors. These fungi can survive and replicate within macrophages, leading to potential CNS invasion. Age-related immune system changes may increase the risk of cryptococcal infections, highlighting the importance of understanding the mechanisms involved.
Link: https://doi.org/10.3389/fimmu.2024.1410090
