The myelination of axons in the nervous system is crucial for proper functioning. Age-related degradation of myelin can lead to cognitive impairment. Researchers have discovered a regulator, C1ql1, that influences oligodendrocyte production and myelin repair. Increasing C1ql1 expression may offer a promising avenue for therapies to treat demyelinating conditions and reverse age-related damage. This finding holds potential for the development of novel treatments for diseases like multiple sclerosis.