Autophagy of the Endoplasmic Reticulum Appears Important in Life Span
The endoplasmic reticulum is a crucial cell structure involved in protein folding and transport. It undergoes autophagy, a maintenance process where damaged components are recycled. Researchers highlight the significance of ER autophagy in lifespan, drawing parallels to aging and mitochondria. ER remodeling during aging impacts proteomic composition and function. Understanding ER-phagy as a protective mechanism in aging sheds light on longevity mechanisms.
Studies show that ER remodeling is a common feature of aging across various species. In C. elegans, aging leads to decreased ER mass and a shift in morphology from rough sheets to tubular structures. ER-phagy, activated in adulthood, plays a role in this remodeling process by clearing rough ER in response to increased protein-folding demand. Impairment of ER-phagy affects lifespan, emphasizing its importance in aging and longevity. The dynamic nature of ER morphology and function reveals a novel aspect of aging mechanisms.
Link: https://doi.org/10.1101/2024.08.07.607085
