The accumulation of senescent cells is a key contributor to age-related dysfunction and disease. These cells are normally destroyed by programmed cell death or the immune system, but in aging, their numbers increase. Senescent cells secrete pro-inflammatory signals that can lead to tissue damage and loss of function, affecting organs like the heart. While cardiomyocytes are non-dividing cells, they can still become senescent due to factors like oxidative stress and inflammation. Strategies to eliminate senescent cells, known as senolysis, show promise in improving cardiac function. Various approaches, including senolytic drugs and immunogenetic interventions, are being explored. Understanding the mechanisms of cardiomyocyte senescence is crucial for developing effective and safe senolytic therapies for the aging heart.
Towards Senolytic Therapies to Treat the Aging Heart – Fight Aging!
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