Nonlinear Aging in Humans, with Transitions Points of Increased Risk
This study delves into the intricate process of nonlinear aging in humans, shedding light on crucial transition points that escalate the risk of age-related diseases. Different from linear aging models, this research identifies pivotal shifts in molecular markers at around 44 and 60 years of age, impacting various biological pathways. The findings emphasize the nonlinear nature of aging, offering valuable insights into understanding and potentially tackling age-related health issues.
Aging is a multifaceted phenomenon intricately linked to numerous diseases. Exploring the molecular intricacies of aging and pinpointing potential therapeutic targets are vital for enhancing the quality of life as we age. While many studies have focused on linear age-related changes, this research underscores the significance of nonlinear molecular alterations that trigger a surge in aging-related ailments after specific timepoints.
Unveiling a comprehensive multi-omics analysis of a longitudinal cohort spanning ages 25 to 75, the study unveils distinct nonlinear patterns in aging markers, with significant disruptions occurring at pivotal points near 44 and 60 years. Unraveling specific molecules and pathways associated with these transitions, such as immune modulation, carbohydrate metabolism, cardiovascular disease risk, lipid metabolism, and alcohol metabolism changes, provides crucial insights into the evolving landscape of aging.
By elucidating the nonlinear progression of aging-related diseases and the underlying molecular mechanisms, this study offers a deeper understanding of the aging process and opens avenues for targeted interventions to enhance healthspan.
Link: https://doi.org/10.1038/s43587-024-00692-2
