Autophagy Regulator MYTHOS Required for Some Life Extending Interventions in Nematode Worms
Researchers have found that autophagy, a crucial cellular process responsible for recycling damaged components, plays a key role in life extension through interventions like calorie restriction. A recently discovered autophagy regulator gene called MYTHOS is essential for various life-extending genetic interventions to be effective in nematode worms. This gene, which is present in both humans and worms, becomes more active with age, indicating an adaptive response to combat cellular dysfunction. While MYTHOS itself may not be a direct target for intervention, its discovery adds to the evidence supporting the development of therapies that enhance autophagy to slow down aging.
Cell senescence and aging result from the gradual accumulation of faulty organelles and cellular damage, impacting proteostasis and protein quality control systems. Autophagy, a vital cellular maintenance process, helps remove damaged components and sustains core cellular functions. A protein named MYTHO has been identified as a regulator of aging and health span, with its absence leading to decreased lifespan and reduced survival under stress conditions in nematode worms. MYTHO’s role in mediating responses to germline signals and dietary cues highlights its importance in promoting stress resistance and healthy aging.
