The commensal microbiomes of the body, such as those in the gut and oral cavity, undergo detrimental changes with age. One key mechanism is the reduced production of immunoglobulin A antibodies, which play a crucial role in shaping the microbiome. Researchers have found evidence that senescent B cells near mucous membranes contribute to this decline in immunoglobulin A production, impacting both gut and oral microbiomes. Understanding these age-related changes in microbiota could lead to new strategies for controlling them.
Senescent B Cells Implicated in the Reduced Production of Immunoglobulin A and Consequent Microbiome Changes
