A Distinct Fungal Gut Mycobiome Found in Long-Lived Individuals – Fight Aging!

Recent research has uncovered a unique fungal gut mycobiome in long-lived individuals, shedding light on the importance of gut microbiota in aging. A study conducted on a group of 251 participants ranging from 24 to 108 years old, including 47 centenarians, revealed significant variations in the gut mycobiome with age. Core fungal taxa such as Penicillium and Aspergillus were found to be maintained in long-lived individuals, while the Candida enterotype was enriched compared to older counterparts. This enterotype was also associated with a bacteria enterotype dominated by Bacteroides, commonly found in young and centenarians. The study identified unique fungal signatures in long-lived individuals, suggesting that the gut mycobiome evolves with age. These findings highlight the potential benefits of understanding and manipulating the gut mycobiome to improve health in aging individuals.

Link: https://doi.org/10.1016/j.isci.2024.110412