Our bodies are complex systems where organs rely on each other for optimal function. When one organ is affected by age-related disease, it can impact the entire body. Researchers have found that patients with chronic liver disease experience accelerated epigenetic aging in other tissues, such as skeletal muscle and the immune system. This accelerated aging can lead to physical frailty, reduced immunity, and ultimately increased mortality. Understanding the mechanisms behind this aging process could lead to early interventions to improve patient outcomes.